British Journal of Cancer Management

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The use of imatinib in chronic myeloid leukaemia
BJCM, Volume 1, Number 3.

Chronic myeloid leukaemia (CML) is an uncommon disease that, over the last five decades, has provided seminal discoveries about cancer biology. The vast majority of cases have a cytogenetic abnormality known as the Philadelphia (Ph) chromosome, which comprises a reciprocal translocation between chromosomes 9 and 22.

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